The Structure of Ribosome Inactivating Proteins

Author(s): Jon D. Robertus , Arthur F. Monzingo .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 4 , Issue 5 , 2004

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Abstract:

Ribosome Inactivating Proteins, RIPs, depurinate an invariant adenine from the 28S rRNA of eukaryotic ribosomes; they have evolved to near enzymatic perfection for this task. The N-glycosidase fold is conserved in plant and bacterial enzymes. RIPs can form complexes with cell surface recognition proteins that dramatically increase the cytotoxicity of the molecule.

Keywords: ribosome inactivating proteins, 28s rrna, eukaryotic ribosomes

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Article Details

VOLUME: 4
ISSUE: 5
Year: 2004
Page: [477 - 486]
Pages: 10
DOI: 10.2174/1389557043403837
Price: $58

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