A Synthetic Route to Cell Permeable, Macrocyclic-Based Phosphonate Acyloxymethyl Esters

Title: A Synthetic Route to Cell Permeable, Macrocyclic-Based Phosphonate Acyloxymethyl Esters

Volume: 1 Issue: 2

Author(s): Medardo R. Chavez, Piyu Zhao, Zoltan Kovacs and A. Dean Sherry

Affiliation:

Keywords: intracellular probes, ca and mg indicators, 31p nmr

Abstract: Four cell membrane-permeant derivatives of polyaza macrocyclic ligands, including acetoxymethyl (AM) and pivaloyloxymethyl (POM) esters of 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetrakis(ethyl methylenephosphonate) (DOTPME) and 1,4,7-triazacyclononane- 1,4,7-tris(ethyl methylenephosphonate) (NOTPME), were prepared as model systems for the detection of intracellular ions by 31P NMR spectroscopy. Preliminary results on isolated perfused rat hearts suggest that such ligands may be useful for monitoring intracellular levels of Ca2+ and Mg2+.

Cite this article as:

Chavez R. Medardo, Zhao Piyu, Kovacs Zoltan and Sherry Dean A., A Synthetic Route to Cell Permeable, Macrocyclic-Based Phosphonate Acyloxymethyl Esters, Letters in Organic Chemistry 2004; 1 (2) . https://dx.doi.org/10.2174/1570178043488374