A Synthetic Route to Cell Permeable, Macrocyclic-Based Phosphonate Acyloxymethyl Esters

Author(s): Medardo R. Chavez, Piyu Zhao, Zoltan Kovacs, A. Dean Sherry.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 2 , 2004

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Four cell membrane-permeant derivatives of polyaza macrocyclic ligands, including acetoxymethyl (AM) and pivaloyloxymethyl (POM) esters of 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetrakis(ethyl methylenephosphonate) (DOTPME) and 1,4,7-triazacyclononane- 1,4,7-tris(ethyl methylenephosphonate) (NOTPME), were prepared as model systems for the detection of intracellular ions by 31P NMR spectroscopy. Preliminary results on isolated perfused rat hearts suggest that such ligands may be useful for monitoring intracellular levels of Ca2+ and Mg2+.

Keywords: intracellular probes, ca and mg indicators, 31p nmr

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Article Details

Year: 2004
Page: [194 - 200]
Pages: 7
DOI: 10.2174/1570178043488374
Price: $65

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