Synthesis of N-(Trimethylsilylethoxycarbonyl)-deoxycytidine and Deoxyadenosine Derivatives as Key Intermediates for the DNA Synthesis using Fluoride Ion-Promoted Deprotection Strategy

Author(s): Mitsuo Sekine , Masanori Tobe , Takashi Nagayama , Takeshi Wada .

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 2 , 2004

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Abstract:

An improved method for the synthesis of trimethylsilylethyl chloroformate (Teoc-Cl) was studied in great detail. N-Teoc-adenosine, N-Teoccytidine and their deoxyribonucleoside derivatives were synthesized as the key synthetic intermediates for the synthesis of base-sensitive oligonucleotide derivatives by use of N-methylimidazole. The stability and chemical properties of these Nprotected nucleoside derivatives were examined.

Keywords: teoc group, base-sensitive, n-protected nucleosides, dna/rna chemical synthesis

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Article Details

VOLUME: 1
ISSUE: 2
Year: 2004
Page: [179 - 182]
Pages: 4
DOI: 10.2174/1570178043488419
Price: $58

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