Cytotoxic Resibufogenin Transformation Products from Cell Suspension Cultures of Platycodon Grandiflorum

Author(s): Lixin Li, Ping Li, Min Ye, Lei Zhong, Dean Guo.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 2 , 2004

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Four biotransformed products of resibufogenin were obtained after 4 days of incubation with cell suspension cultures of Platycodon grandiflorum. On the basis of chemical and spectral data, their structures were elucidated as 3-epi-resibufogenin, marinobufagin, 1β-hydroxy-resibufogenin, and 3-epi-marinobufagin respectively, among which the latter two compounds are new. These compounds were found to exhibit potent cytotoxic activities against Bel-7402, BGC-823, HeLa, and HL-60 human cancer cell lines.

Keywords: platycodon grandiflorum, campanulaceae, resibufogenin, biotransformation

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Article Details

Year: 2004
Page: [176 - 178]
Pages: 3
DOI: 10.2174/1570178043488509
Price: $65

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