Enzymatic Oxidation of 1,4- and 1,8-Cineole using Plant Cultured Cells of Catharanthus Roseus

Title: Enzymatic Oxidation of 1,4- and 1,8-Cineole using Plant Cultured Cells of Catharanthus Roseus

Volume: 1 Issue: 2

Author(s): Hiroki Hamada, Kohji Ishihara, Nobuyoshi Nakajima, Hatsuyuki Hamada, Howard J. Williams and Alastair I. Scott

Affiliation:

Keywords: 1,8-cineole, catharanthus roseus, biotransformation organism

Abstract: Oxidases present in plant cultured cells of Catharanthus roseus can hydroxylate saturated centers of natural products without double bond activation. When starting materials were 1,8- or 1,4-cineole, secondary and tertiary alcohols were produced and identified using NMR and mass spectroscopy. Our results indicate that hydroxylation position and stereochemistry are determined by the biotransformation organism.

Cite this article as:

Hamada Hiroki, Ishihara Kohji, Nakajima Nobuyoshi, Hamada Hatsuyuki, Williams J. Howard and Scott I. Alastair, Enzymatic Oxidation of 1,4- and 1,8-Cineole using Plant Cultured Cells of Catharanthus Roseus, Letters in Organic Chemistry 2004; 1 (2) . https://dx.doi.org/10.2174/1570178043488455