Enzymatic Oxidation of 1,4- and 1,8-Cineole using Plant Cultured Cells of Catharanthus Roseus

Author(s): Hiroki Hamada, Kohji Ishihara, Nobuyoshi Nakajima, Hatsuyuki Hamada, Howard J. Williams, Alastair I. Scott.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 2 , 2004

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Abstract:

Oxidases present in plant cultured cells of Catharanthus roseus can hydroxylate saturated centers of natural products without double bond activation. When starting materials were 1,8- or 1,4-cineole, secondary and tertiary alcohols were produced and identified using NMR and mass spectroscopy. Our results indicate that hydroxylation position and stereochemistry are determined by the biotransformation organism.

Keywords: 1,8-cineole, catharanthus roseus, biotransformation organism

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Article Details

VOLUME: 1
ISSUE: 2
Year: 2004
Page: [171 - 172]
Pages: 2
DOI: 10.2174/1570178043488455
Price: $58

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