Fine-Tuning of Acid Susceptibility of 4, 4 ’ -Dimethoxytrityl Ether Derivatives by a Methoxy Group Introduced via a Styryl Substituent

Author(s): Kohji Seio, Takahide Sasaki, Mitsuo Sekine.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 2 , 2004

Become EABM
Become Reviewer


To overcome the problem of depurination in oligoDNA synthesis, we tried to fine-tune the acid lability of the DMTr group by adding a substituted styryl group on the phenyl ring. The styryl groups could buffer the electron donating nature of the methoxy group and enabled the fine-tuning of the acid lability.

Keywords: protecting group, trityl group, oligodeoxynucleotide synthesis, depurination

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2004
Page: [159 - 162]
Pages: 4
DOI: 10.2174/1570178043488428
Price: $65

Article Metrics

PDF: 4