Fine-Tuning of Acid Susceptibility of 4, 4 ’ -Dimethoxytrityl Ether Derivatives by a Methoxy Group Introduced via a Styryl Substituent

Author(s): Kohji Seio, Takahide Sasaki, Mitsuo Sekine.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 2 , 2004

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Abstract:

To overcome the problem of depurination in oligoDNA synthesis, we tried to fine-tune the acid lability of the DMTr group by adding a substituted styryl group on the phenyl ring. The styryl groups could buffer the electron donating nature of the methoxy group and enabled the fine-tuning of the acid lability.

Keywords: protecting group, trityl group, oligodeoxynucleotide synthesis, depurination

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Article Details

VOLUME: 1
ISSUE: 2
Year: 2004
Page: [159 - 162]
Pages: 4
DOI: 10.2174/1570178043488428
Price: $58

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