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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Fine-Tuning of Acid Susceptibility of 4, 4 ’ -Dimethoxytrityl Ether Derivatives by a Methoxy Group Introduced via a Styryl Substituent

Author(s): Kohji Seio, Takahide Sasaki and Mitsuo Sekine

Volume 1, Issue 2, 2004

Page: [159 - 162] Pages: 4

DOI: 10.2174/1570178043488428

Price: $65

Abstract

To overcome the problem of depurination in oligoDNA synthesis, we tried to fine-tune the acid lability of the DMTr group by adding a substituted styryl group on the phenyl ring. The styryl groups could buffer the electron donating nature of the methoxy group and enabled the fine-tuning of the acid lability.

Keywords: protecting group, trityl group, oligodeoxynucleotide synthesis, depurination


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