Synthesis and Cellular Uptake of Fluorescently Labeled 1-Chloromethyl-5- Hydroxy-1, 2-Dihydro-3H-Benz [e] Indole (Seco-CBI)- Pyrrole Polyamide Conjugates

Author(s): Rohtash Kumar, Dinesh Rai, Sandra L. Marcus, Simon Ching Chun Ko, J. William Lown.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 2 , 2004

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The synthesis is described of 1-chloromethyl-5-hydroxy-1, 2-dihydro-3H-benz [e] indole (seco- CBI)- pyrrole polyamide conjugates (1-4) which were labeled with a fluorescent Fmoc moiety to evaluate their cellular uptake. Confocal laser scanning microscopy (CLSM) indicates that these DNA minor groove-binding agents localize in the cytoplasm and organelles.

Keywords: 1-chloromethyl-5-, hydroxy-1, 2-dihydro-3h-benz [e] indole, pyrrole polyamide conjugates, fluorescent fmoc, groove-binding agents

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Article Details

Year: 2004
Page: [154 - 158]
Pages: 5
DOI: 10.2174/1570178043488383
Price: $65

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