Dual Acting Antihistaminergic Agents

Author(s): R. T. Scannell, E. Differding, P. Talaga.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 4 , Issue 9 , 2004

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Abstract:

Histamine is a primary mediator in allergic response and acts in concert with other agents to impact disease progression. Respiratory disorders such as asthma, rhinitis and dermatological conditions such as urticaria involve histamine along with other mediators. An antihistamine that possesses an additional property of counteracting the effects mediated by these other mediators should offer some therapeutic benefit over a selective antihistaminergic agent.

Keywords: dual h1 antihistamine, 5-lo, ltd4, h2 antihistamine, h3 antihistamine, h4 antihistamine, paf, neurokinin, tachykinin, thromboxane a2

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Article Details

VOLUME: 4
ISSUE: 9
Year: 2004
Page: [923 - 933]
Pages: 11
DOI: 10.2174/1389557043403251
Price: $58

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