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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Dual Acting Antihistaminergic Agents

Author(s): R. T. Scannell, E. Differding and P. Talaga

Volume 4, Issue 9, 2004

Page: [923 - 933] Pages: 11

DOI: 10.2174/1389557043403251

Price: $65

Abstract

Histamine is a primary mediator in allergic response and acts in concert with other agents to impact disease progression. Respiratory disorders such as asthma, rhinitis and dermatological conditions such as urticaria involve histamine along with other mediators. An antihistamine that possesses an additional property of counteracting the effects mediated by these other mediators should offer some therapeutic benefit over a selective antihistaminergic agent.

Keywords: dual h1 antihistamine, 5-lo, ltd4, h2 antihistamine, h3 antihistamine, h4 antihistamine, paf, neurokinin, tachykinin, thromboxane a2


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