Abstract
Histamine is a primary mediator in allergic response and acts in concert with other agents to impact disease progression. Respiratory disorders such as asthma, rhinitis and dermatological conditions such as urticaria involve histamine along with other mediators. An antihistamine that possesses an additional property of counteracting the effects mediated by these other mediators should offer some therapeutic benefit over a selective antihistaminergic agent.
Keywords: dual h1 antihistamine, 5-lo, ltd4, h2 antihistamine, h3 antihistamine, h4 antihistamine, paf, neurokinin, tachykinin, thromboxane a2
Mini-Reviews in Medicinal Chemistry
Title: Dual Acting Antihistaminergic Agents
Volume: 4 Issue: 9
Author(s): R. T. Scannell, E. Differding and P. Talaga
Affiliation:
Keywords: dual h1 antihistamine, 5-lo, ltd4, h2 antihistamine, h3 antihistamine, h4 antihistamine, paf, neurokinin, tachykinin, thromboxane a2
Abstract: Histamine is a primary mediator in allergic response and acts in concert with other agents to impact disease progression. Respiratory disorders such as asthma, rhinitis and dermatological conditions such as urticaria involve histamine along with other mediators. An antihistamine that possesses an additional property of counteracting the effects mediated by these other mediators should offer some therapeutic benefit over a selective antihistaminergic agent.
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Cite this article as:
Scannell T. R., Differding E. and Talaga P., Dual Acting Antihistaminergic Agents, Mini-Reviews in Medicinal Chemistry 2004; 4 (9) . https://dx.doi.org/10.2174/1389557043403251
DOI https://dx.doi.org/10.2174/1389557043403251 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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