Pharmacokinetic Study and Trial for Preparation of Enteric-Coated Capsule Containing Insulinomimetic Vanadyl Compounds: Implications for Clinical Use

Author(s): H. Sakurai , J. Fugono , H. Yasui .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 4 , Issue 1 , 2004

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Abstract:

To treat patients suffering from diabetes mellitus, we developed several types of orally active vanadyl complexes to replace painful insulin injections, and prepared them in the form of enteric-coated capsules containing vanadium compounds. Pharmacokinetic analysis demonstrated that these capsules enhance the bioavailability of pharmacologically active vanadyl species.

Keywords: Vanadyl compound, insulinomimetic activity, diabetes mellitus, blood circulation monitoring-electron, paramagnetic resonance (BCM-EPR), pharmacokinetic analysis, bioavailability, enteric-coated capsule

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Article Details

VOLUME: 4
ISSUE: 1
Year: 2004
Page: [41 - 48]
Pages: 8
DOI: 10.2174/1389557043487574

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