Abstract
The following review discusses the successful application of X-ray, NMR, and molecular modeling in the design of potent and selective inhibitors of matrix metalloproteinases (MMPs) and TNFα-converting enzyme (TACE) from Wyeth. The importance of protein and ligand mobility as it impacts structure-based design is also discussed. The MMPs are an active target for a variety of diseases, including cancer and arthritis.
Keywords: structure-based drug design, matrix metalloproteinase, matrix metalloprotease, x-ray, nmr, molecular modeling, inhibitor, mmp
Current Topics in Medicinal Chemistry
Title: The Application of X-ray, NMR, and Molecular Modeling in the Design of MMP Inhibitors
Volume: 4 Issue: 12
Author(s): Thomas S. Rush III and Robert Powers
Affiliation:
Keywords: structure-based drug design, matrix metalloproteinase, matrix metalloprotease, x-ray, nmr, molecular modeling, inhibitor, mmp
Abstract: The following review discusses the successful application of X-ray, NMR, and molecular modeling in the design of potent and selective inhibitors of matrix metalloproteinases (MMPs) and TNFα-converting enzyme (TACE) from Wyeth. The importance of protein and ligand mobility as it impacts structure-based design is also discussed. The MMPs are an active target for a variety of diseases, including cancer and arthritis.
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Cite this article as:
Rush III S. Thomas and Powers Robert, The Application of X-ray, NMR, and Molecular Modeling in the Design of MMP Inhibitors, Current Topics in Medicinal Chemistry 2004; 4 (12) . https://dx.doi.org/10.2174/1568026043387999
DOI https://dx.doi.org/10.2174/1568026043387999 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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