Title: Regioselective Control of Electrophilic Aromatic Substitution Reactions
VOLUME: 1 ISSUE: 3
Author(s):Keith Smith and Gamal A. El-Hiti
Affiliation:Centre for Clean Chemistry, Department of Chemistry, University of Wales Swansea, Singleton Park,Swansea, SA2 8PP, UK
Keywords:regioisomers, zeolites, electrophilic aromatic substitution reactions, directed lithiation, shape selectivity, heterocycles
Abstract: para-Regioselective electrophilic aromatic substitution reactions, for example nitration, alkylation, acylation, sulfonylation and halogenation, can be achieved by carrying out reactions over solid catalysts such as zeolites, under modest conditions via shape-selectivity. By contrast, organolithium reagents can play an important role when ortho-products are desirable. ortho-Lithiation has been applied for the synthesis of more complex substituted heterocycles that are difficult to prepare by other means.
