Chromosome 17 in Fronto Temporal Lobak Degeneration (FTLD): From MAPT to Progranulin and Back

Author(s): A. Alberici, M. Cosseddu, A. Padovani, B. Borroni.

Journal Name:Current Alzheimer Research

Volume 8 , Issue 3 , 2011

Abstract:

Frontotemporal Lobar degeneration (FTLD) is one of the most important neurodegenerative conditions, affecting in the presenium, but more recently recognized also in aged population. The strong genetic background, along with autopsy determinations prompted the identification of the two major genes associated to the disease: MAPT gene, and Progranulin (PGRN) gene. In this review, we highlighted the milestones of these discoveries, and their implication for the development of future therapeuthical approaches.

Keywords: Fronto temporal lobak degeneration, MAPT, progranulin, DLDH, PNFA, CBS, PSP, frontal atrophy, FTLD-MND, CHMP2B, language dysfunction, (TAR)-DNA-binding, NCI, ALS

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2011
Page: [229 - 236]
Pages: 8
DOI: 10.2174/156720511795563737
Price: $58