Syntheses and Biological Activities of Iminosugars as α-L-Fucosidase Inhibitors

Author(s): Elena Moreno-Clavijo, Ana T. Carmona, Antonio J. Moreno-Vargas, Lidia Molina, Inmaculada Robina.

Journal Name: Current Organic Synthesis

Volume 8 , Issue 1 , 2011

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Abstract:

A review dealing with iminosugars as inhibitors of α-L-fucosidases is presented. The different synthetic approaches for the preparation of the most relevant ones as well as their inhibitory properties are presented.

Keywords: Azafagomines, hydroxylated azepanes, piperidines, pyrrolidines, fucosidase inhibitors, iminosugars, azasugars, L-Fucosidase Inhibitors, glycosylation, glycosylation reactions, hydrolysis, glycoconjugates, carcinomas, L-fucosidases, Thermotoga maritima, Thermotoga maritima enzyme, iminocyclitols, hydrophobic, POLYHYDROXYLATED PYRROLIDINES, meso-pyrrolidine 1, human placenta, chromatography, Holzapfel, Crous method, Oxime, Bayon's method, pyrrolidinethylphosphonate, nitrone, Cope-House cyclization, tetraacetate, POLYHYDROXYLATED PIPERIDINES, POLYHYDROXYHEXAHYDROPYRIDAZINES, POLYHYDROXYAZEPANES

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Article Details

VOLUME: 8
ISSUE: 1
Year: 2011
Page: [102 - 133]
Pages: 32
DOI: 10.2174/157017911794407700

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