Michael Addition of Nitroalkanes to Optically Active Acrylates Mediated by Cetyltrimethylammonium Hydroxide (CTAOH)

Author(s): Roberto Ballini, Dennis Fiorini, Alessandro Palmieri, Marino Petrini.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 4 , 2004

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Abstract:

Nitroalkanes react with chiral acrylates in the presence of a catalytic amount (10% mol) of CTAOH in small amount of water as solvent. Although only modest levels of diastereoselectivity can be observed in this process, the obtained Michael adducts can be easily transformed into interesting building blocks as γ-amino acids and cyclic hydroxycarbamates.

Keywords: conjugate addition, nitroalkanes, diastereoselective reaction

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Article Details

VOLUME: 1
ISSUE: 4
Year: 2004
Page: [335 - 339]
Pages: 5
DOI: 10.2174/1570178043400677
Price: $58

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