A Direct Route to Erythrinanes v i a α-Amidoalkylation, Conjugate Addition and Ring-Closing Metathesis Reactions

Title: A Direct Route to Erythrinanes v i a α-Amidoalkylation, Conjugate Addition and Ring-Closing Metathesis Reactions

Volume: 1 Issue: 4

Author(s): Inaki Osante, Nuria Sotomayor and Esther Lete

Affiliation:

Keywords: erythrina alkaloids, amidoalkylation, conjugate addition, lithiation, ring-closing metathesis

Abstract: A direct route to erythrinanes has been completed by a sequence that involves diastereoselective conjugate addition on a α,β-unsaturated lactam, followed by a ring-closing metathesis reaction to construct ring A. The synthesis of the key intermediates C-10b functionalized dihydropyrroloisoquinolines is achieved via Parham cyclisation and α-amidoalkylation reactions.

Cite this article as:

Osante Inaki, Sotomayor Nuria and Lete Esther, A Direct Route to Erythrinanes v i a α-Amidoalkylation, Conjugate Addition and Ring-Closing Metathesis Reactions, Letters in Organic Chemistry 2004; 1 (4) . https://dx.doi.org/10.2174/1570178043400712