Title: Total Syntheses of Macrosphelides C, F, G and H
VOLUME: 1 ISSUE: 4
Author(s):Yuichi Kobayashi, Yong-Gang Wang and Hukum P. Acharya
Affiliation:Department of Biomolecular Engineering, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.
Keywords:macrosphelide, asymmetric synthesis, wacker oxidation, furan, furan oxidation
Abstract: The title macrosphelides were synthesized by using two-step conversion of furans into γ-oxo-α,β- unsaturated carboxylic acids as a key step. In the case of macrosphelide H, AcCH2 group at C(3) was constructed from CH2=CHCH2 by Wacker oxidation under modified conditions.
