α-Synuclein Aggregation

Author(s): Angela M. Bodles, G. Brent Irvine.

Journal Name: Protein & Peptide Letters

Volume 11 , Issue 3 , 2004

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Abstract:

α-Synuclein is a major component of Lewy bodies in Parkinsons disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of α-synuclein to aggregate and form fibrillar deposits seems central to its pathology. We have defined a sequence within the NAC region of α-synuclein that is necessary for aggregation. Exploitation of chemically modified analogues of this peptide may produce inhibitors of aggregation.

Keywords: synuclein, amyloid, aggregation, parkinsons disease

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Article Details

VOLUME: 11
ISSUE: 3
Year: 2004
Page: [271 - 279]
Pages: 9
DOI: 10.2174/0929866043407084
Price: $58

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