α-Synuclein and the Pathogenesis of Parkinsons Disease

Author(s): Francis L. Martin , Sally J.M. Williamson , Katerina E. Paleologou , David Allsop , Omar M.A. El-Agnaf .

Journal Name: Protein & Peptide Letters

Volume 11 , Issue 3 , 2004

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Abstract:

Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinsons disease (PD) patients. Intracellular aggregation of α-synuclein (α-syn) appears to play a key role in the generation of LBs and LNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.

Keywords: dna single-strand breaks, comet assay, reactive oxygen species, environmental causation

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Article Details

VOLUME: 11
ISSUE: 3
Year: 2004
Page: [229 - 237]
Pages: 9
DOI: 10.2174/0929866043407138
Price: $58

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