Assembly In Vitro of Tau Protein and its Implications in Alzheimers Disease

Author(s): Jesus Avila, Mar Perez, Jose J. Lucas, Alberto Gomez-Ramos, Ismael Santa Maria, Francisco Moreno, Mark Smith, George Perry, Felix Hernandez.

Journal Name: Current Alzheimer Research

Volume 1 , Issue 2 , 2004

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Abstract:

Tau is a microtubule associated protein that is also the main component of the aberrant filaments that form aberrant structures like the neuropil threads or the neurofibrillary tangles, found in the brain of Alzheimers disease patients. The assembly of tau aberrant filaments could be reproduced in vitro by using a high concentration of tau protein or, at lower protein concentrations, by adding some compounds like polyanions, fatty acids (and derivates), and others. In this mini-review a descriptive analysis of the different conditions needed for in vitro tau polymerization are summarized.

Keywords: tau, assembly, polyanions, fatty acids and derivates

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Article Details

VOLUME: 1
ISSUE: 2
Year: 2004
Page: [97 - 101]
Pages: 5
DOI: 10.2174/1567205043332207
Price: $58

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