Neuroprotection by the α2-Adrenoceptor Agonist, Dexmedetomidine, in Experimental Stroke Models

Author(s): Kirsi Puurunen, Jukka Jolkkonen, Juhani Sivenius.

Journal Name: Vascular Disease Prevention

Volume 1 , Issue 2 , 2004

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Abstract:

Dexmedetomidine is a selective α2-adrenoceptor agonist, which has been shown to be neuroprotective in experimental cerebral ischemia models. Dexmedetomidine administration induces sedation and it has been used as a veterinary sedative in a racemic mixture called medetomidine and recently also clinically in the intensive care unit. Dexmedetomidine treatment has been found to be neuroprotective in cerebral ischemia and some excitotoxic models. The neuroprotective effect of dexmedetomidine could be utilised in prevention of ischemic damage and memory disturbances following by major surgery causing cerebrovascular events.

Keywords: alpha-adrenergic, brain, dexmedetomidine, ischemia, neuroprotection

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Article Details

VOLUME: 1
ISSUE: 2
Year: 2004
Page: [117 - 122]
Pages: 6
DOI: 10.2174/1567270010401020117
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