Synthetic Studies on N-Methylwelwitindolinone C Isothiocyanate (Welwistatin) and Related Substructures
Carmen Avendano and J. Carlos Menendez
Affiliation: Departamento de Quimica Organica y Farmaceutica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
N-Methylwelwitindolinone C isothiocyanate (welwistatin), isolated from the blue-green alga Hapalosiphon welwitschii, is a potent MDR inhibitor. This review deals with synthetic efforts aimed at welwistatin itself or its fragments, together with work concerning the bicyclo[4.3.1]decane and cyclohepta[cd]indole systems, which are related to the CD and ABC fragments of the natural product.
Keywords: bicyclo decanes, rhodium carbenoids, aryllead triacetates, ring-closing metathesis, multi-drug resistance
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