New Developments on Thromboxane Modulators

Author(s): Jean-Michel Dogne, Julien Hanson, Xavier de Leval, Bernard Masereel, Philippe Kolh, Bernard Pirotte.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 4 , Issue 6 , 2004

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Abstract:

Thromboxane A2 (TXA2) is a labile product formed from arachidonic acid by cyclooxygenase. The pathogenesis of numerous cardiovascular, pulmonary, and thromboembolic diseases can be related to this metabolite. Therefore, TXA2 modulators have been developed for 20 years. This review will highlight the evolution in the field of TXA2 modulators.

Keywords: thromboxane a2, arachidonic acid, thromboxane synthase, prostanoids

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Article Details

VOLUME: 4
ISSUE: 6
Year: 2004
Page: [649 - 657]
Pages: 9
DOI: 10.2174/1389557043403684
Price: $58

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