Structural Approach for COX-2 Inhibition

Author(s): C. Michaux, C. Charlier.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 4 , Issue 6 , 2004

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Abstract:

The design of selective COX-2 inhibitors is a new approach to obtain potent, anti-inflammatory drugs but with less side effects. Several families of such inhibitors were reported in literature. In this review, the drug design processes used to understand their binding mode and the origin of selectivity of these compounds are described.

Keywords: cox-2 inhibitor, selectivity, molecular modelling, x-ray, drug design, cox binding site, molecular features

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Article Details

VOLUME: 4
ISSUE: 6
Year: 2004
Page: [603 - 615]
Pages: 13
DOI: 10.2174/1389557043403756
Price: $65

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