First and Second Generations of COX-2 Selective Inhibitors

Author(s): Xavier de Leval, Fabien Julemont, Valerie Benoit, Michel Frederich, Bernard Pirotte, Jean-Michel Dogne.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 4 , Issue 6 , 2004

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The identification and characterization of the inducible form of cyclooxygenases (COX-2) stimulated the investigations to develop efficient, non-steroidal anti-inflammatory drugs (NSAIDs) with reduced side effects (essentially gastro-intestinal toxicity) compared to classical NSAIDs. This review focuses on the chemical and pharmacological properties (pre-clinical data) of marketed COX-2 inhibitors.

Keywords: cox-2 inhibitors, cox-2 selectivity, pre-clinical data

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Article Details

Year: 2004
Page: [597 - 601]
Pages: 5
DOI: 10.2174/1389557043403693
Price: $58

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