Complementary Peptide Epitopes and Antiidiotypic Antibodies in Autoimmunity

Author(s): Maria Sakarellos-Daitsiotis, Manh-Thong Cung, Constantinos Sakarellos, Zouhair El Hilali, Aggeliki Kosmopoulou, Chryssa Voitharou.

Journal Name: Protein & Peptide Letters

Volume 11 , Issue 4 , 2004

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Abstract:

Application of complementary B and T cell epitopes in inducing anti-idiotypic and anticlonotypic antibodies capable of regulating or suppressing the autoimmune responses in experimental autoimmune myasthenia gravis (EAMG), allergic neuritis (EAN) and allergic encephalomyelitis (EAE) has been the stimulus of many research efforts. Studies on the idiotypic / anti-idiotypic network of anti-La / SSB positive sera from patients with Sjogrens Syndrome (SS) and Systemic Lupus Erythematosus (SLE) and on animals immunized with the complementary epitopes are presented.

Keywords: complementary epitopes, autoimmune diseases, anti-idiotypic antibodies

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Article Details

VOLUME: 11
ISSUE: 4
Year: 2004
Page: [367 - 375]
Pages: 9
DOI: 10.2174/0929866043407020
Price: $65

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