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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Crystallization and Preliminary X-Ray Crystallographic Analysis of Plasmodium Falciparum S-Adenosyl-L-Homocysteine Hydrolase

Author(s): Nobutada Tanaka, Yoshio Kusakabe, Katsura Shiraiwa, Yasumitsu Sakamoto, Masayuki Nakanishi, Yukio Kitade and Kazuo T. Nakamura

Volume 11, Issue 2, 2004

Page: [201 - 205] Pages: 5

DOI: 10.2174/0929866043478248

Price: $65

Abstract

S-adenosyl-L-homocysteine hydrolase from a malaria parasite Plasmodium falciparum (PfSAHH) has been crystallized by the vapor diffusion method. The crystals belong to an orthorhombic space group P212121 with the cell dimensions of a = 76.66 Å, b = 86.31 Å, and c = 335.6 Å. There are four subunits (one tetramer) per asymmetric unit. X-ray diffraction data have been collected up to 2.8 Å resolution. Selfrotation function studies suggest that the tetrameric PfSAHH molecule has the 222 point group symmetry.

Keywords: Plasmodium, S-adenosyl-L-homocysteine, hydrolase, orthorhombic

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