Crystallization and Preliminary X-Ray Crystallographic Analysis of Plasmodium Falciparum S-Adenosyl-L-Homocysteine Hydrolase

Author(s): Nobutada Tanaka, Yoshio Kusakabe, Katsura Shiraiwa, Yasumitsu Sakamoto, Masayuki Nakanishi, Yukio Kitade, Kazuo T. Nakamura.

Journal Name: Protein & Peptide Letters

Volume 11 , Issue 2 , 2004

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S-adenosyl-L-homocysteine hydrolase from a malaria parasite Plasmodium falciparum (PfSAHH) has been crystallized by the vapor diffusion method. The crystals belong to an orthorhombic space group P212121 with the cell dimensions of a = 76.66 Å, b = 86.31 Å, and c = 335.6 Å. There are four subunits (one tetramer) per asymmetric unit. X-ray diffraction data have been collected up to 2.8 Å resolution. Selfrotation function studies suggest that the tetrameric PfSAHH molecule has the 222 point group symmetry.

Keywords: Plasmodium, S-adenosyl-L-homocysteine, hydrolase, orthorhombic

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Article Details

Year: 2004
Page: [201 - 205]
Pages: 5
DOI: 10.2174/0929866043478248
Price: $58

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