Comparative Study of Interaction of Two Type Ii Ribosome-Inactivating Proteins And Their A-Chains With Model Membrane

Author(s): Hong Xu , Bao-Zhong Wang , Wang-Yi Liu .

Journal Name: Protein & Peptide Letters

Volume 11 , Issue 2 , 2004

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Abstract:

Both cinnamomin and ricin are type II ribosome-inactivating proteins. Cinnamomin is less cytotoxic compared with ricin. In order to clarify the mechanism of their different cytotoxicities, the interaction of cinnamomin and its A-chain with model membrane was investigated and compared with that of ricin and its A-chain. It was revealed that cinnamomin is less effective than ricin in interacting with model membrane. Cinnamomin A-chain interacts with model membrane much less violently than ricin Achain. The differences in the interaction of cinnamomin, ricin or their A-chains with model membrane might at least in part indicate the different cytotoxicity between cinnamomin and ricin.

Keywords: aggregation,, cinnamomin,, leakage,, membrane,

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Article Details

VOLUME: 11
ISSUE: 2
Year: 2004
Page: [157 - 163]
Pages: 7
DOI: 10.2174/0929866043478310
Price: $58

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