Differential Desensitization of Somatostatin Receptor Subtypes in AtT-20 Cells

Author(s): Fredric C. Mazza, Allan D. Blake.

Journal Name: Protein & Peptide Letters

Volume 11 , Issue 2 , 2004

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Abstract:

Nonpeptidyl agonists for the somatostatin (SRIF) receptor family have been developed. We have studied the desensitization effects for two of these agonists upon SRIF receptor function in AtT-20 cells, a neuroendocrine tumor cell, which endogenously expresses two distinct SRIF receptor, subtypes. We observe that SRIF and the nonpeptidyl, subtype selective agonists, differentially regulate SRIF receptor subtypes in the AtT-20 cell.

Keywords: Somatostatin,, nonpeptidyl agonists,, receptor subtype,, desensitization,

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Article Details

VOLUME: 11
ISSUE: 2
Year: 2004
Page: [141 - 147]
Pages: 7
DOI: 10.2174/0929866043478239
Price: $58

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