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Mini-Reviews in Organic Chemistry
ISSN (Print): 1570-193X
ISSN (Online): 1875-6298
VOLUME: 1
ISSUE: 1
DOI: 10.2174/1570193043488935









Biomacromolecule Surface Recognition Using Nanoparticles

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Author(s): Catherine M. Goodman and Vincent M. Rotello
Pages 103-114 (12)
Abstract:
Monolayer-protected nanoparticles represent a new class of receptors, capable of high affinity, multivalent binding with biomolecules. Networks of self-optimizing bioactive substituents can be introduced via facile place-exchange of functionalized thiols, approximating the diversified topology of biological surfaces. Extension of these particles to model systems and in catalysis is described.
Keywords:
noncovalent interactions, nanoparticle, monolayer-protected clusters, biomolecular recognition
Affiliation:
Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.