Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Solution-Phase Parallel Synthesis of N-Substituted Isoquinuclidines

Author(s): M. S. Levi, M. O.F. Khan, R. F. Borne.

Abstract:

The naturally-occurring alkaloid ibogaine, found in the West African shrub Tabernanthe iboga, possesses the ability to diminish self-administration of substances of abuse, such as cocaine, heroin and alcohol. This was the lead structure for the design of a 16-member library of N-substituted isoquinuclidines. A solution-phase method for their synthesis is described.

Keywords: Ibogaine, isoquinuclidines, 2-azabicyclo[2.2.2]octanes, parallel synthesis, drug dependence

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Article Details

VOLUME: 1
ISSUE: 4
Year: 2004
Page: [384 - 386]
Pages: 3
DOI: 10.2174/1570180043398597
Price: $58