Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Design and Cytotoxicity Analysis of a Conjugate Containing the New DGalactose- Binding Lectin SELld and the Non-Toxic Type 2 Ribosome- Inactivating Protein Nigrin b

Author(s): Jorge Benitez, M. Angeles Rojo, Raquel Munoz, J. Miguel Ferreras, Pilar Jimenez, Tomas Girbes.

Abstract:

Conjugates containing nigrin b (two-chain RIP) linked to a new lectin (SELld) from Sambucus ebulus L. have been designed. They retain the anti-ribosomal inhibitory activity of nigrin b but, in contrast to nigrin b, they exerted strong cytotoxicity on COLO 320 and HeLa cells, which ran in parallel with DNA fragmentation.

Keywords: nigrin b, selld, ribosome-inactivating proteins, colo 320 cells, cancer therapy, apoptosis

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Article Details

VOLUME: 1
ISSUE: 4
Year: 2004
Page: [361 - 367]
Pages: 7
DOI: 10.2174/1570180043398687
Price: $58