Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

Back

Novel Therapeutic Approaches to Mitochondrial Disease

Author(s): J. A. Ibdah, R. M. Payne.

Abstract:

Defects in mitochondrial function cause serious pediatric morbidity and mortality. Most mitochondrial disorders are caused by nuclear gene defects. To overcome the limitations of viral vectors for delivering gene products to mitochondria, we used protein transfection domains that cross cell membranes to deliver proteins expressed by nuclear genes to mitochondria.

Keywords: fatty acids, oxidation, ptd, tat, fusion proteins, mitochondria

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 1
ISSUE: 4
Year: 2004
Page: [308 - 313]
Pages: 6
DOI: 10.2174/1570180043398506
Price: $58