Neprilysin 2: A Novel Messenger Peptide-Inactivating Metalloprotease

Author(s): Tanja Ouimet.

Journal Name: Protein & Peptide Letters

Volume 11 , Issue 5 , 2004

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Abstract:

Neprilysin 2 is a recently identified glycoprotein displaying the highest degree of sequence identity with neprilysin (EC 3.4.24.11), the prototypical member of the M13 family of zinc-dependent metalloproteases. Whereas neprilysin has been shown to be involved in the inactivation of endogenous messenger peptides, like enkephalins and tachykinins, the true physiological functions of neprilysin 2 remain unknown.

Keywords: neprilysin, neprilysin 2, m13 family of metalloproteases, peptide inactivation, enkephalin, substance p, thiorphan, phosphoramidon

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Article Details

VOLUME: 11
ISSUE: 5
Year: 2004
Page: [479 - 489]
Pages: 11
DOI: 10.2174/0929866043406625
Price: $58

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