Abstract
Neprilysin 2 is a recently identified glycoprotein displaying the highest degree of sequence identity with neprilysin (EC 3.4.24.11), the prototypical member of the M13 family of zinc-dependent metalloproteases. Whereas neprilysin has been shown to be involved in the inactivation of endogenous messenger peptides, like enkephalins and tachykinins, the true physiological functions of neprilysin 2 remain unknown.
Keywords: neprilysin, neprilysin 2, m13 family of metalloproteases, peptide inactivation, enkephalin, substance p, thiorphan, phosphoramidon
Protein & Peptide Letters
Title: Neprilysin 2: A Novel Messenger Peptide-Inactivating Metalloprotease
Volume: 11 Issue: 5
Author(s): Tanja Ouimet
Affiliation:
Keywords: neprilysin, neprilysin 2, m13 family of metalloproteases, peptide inactivation, enkephalin, substance p, thiorphan, phosphoramidon
Abstract: Neprilysin 2 is a recently identified glycoprotein displaying the highest degree of sequence identity with neprilysin (EC 3.4.24.11), the prototypical member of the M13 family of zinc-dependent metalloproteases. Whereas neprilysin has been shown to be involved in the inactivation of endogenous messenger peptides, like enkephalins and tachykinins, the true physiological functions of neprilysin 2 remain unknown.
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Cite this article as:
Ouimet Tanja, Neprilysin 2: A Novel Messenger Peptide-Inactivating Metalloprotease, Protein & Peptide Letters 2004; 11 (5) . https://dx.doi.org/10.2174/0929866043406625
DOI https://dx.doi.org/10.2174/0929866043406625 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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