The Role of Neuropeptide Processing Enzymes in Endocrine (Prostate) Cancer: EC 3.4.24.15 (EP24.15)

Author(s): Todd A. Swanson, Sandra I. Kim, Michael Myers, Amanda Pabon, Keith D. Philibert, Mina Wang, Marc J. Glucksman.

Journal Name: Protein & Peptide Letters

Volume 11 , Issue 5 , 2004

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Abstract:

The zinc metalloendopeptidase EC3.4.24.15 [EP24.15, thimet oligopeptidase], a neuropeptide processing enzyme, is central to the formation and degradation of many bioactive peptides in the neural proteome, and is highly expressed in normal prostate. EP24.15 actions are increased in androgen-dependent prostate cancer compared to androgen-independent; augmented by androgen treatment, and inhibited by clinical GnRH analogs. The “neural” prostate includes: neuropeptides, cognate receptors and processing enzymes regulating signaling of peptide-mediated neural inputs.

Keywords: prostate, cancer, endocrine, proteome, neuropeptide, metallopeptidase, metalloenzyme

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Article Details

VOLUME: 11
ISSUE: 5
Year: 2004
Page: [471 - 478]
Pages: 8
DOI: 10.2174/0929866043406607
Price: $58

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