Dine (Damage-Induced Neuronal Endopeptidase)

Author(s): Sumiko Kiryu-Seo, Hiroshi Kiyama.

Journal Name: Protein & Peptide Letters

Volume 11 , Issue 5 , 2004

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Abstract:

A unique central nervous system (CNS)-specific metalloprotease, DINE / ECEL1 (damage induced neuronal endopeptidase / endothelin converting enzyme-like 1), has recently been added to the M13 / neprilysin (NEP) family. This enzyme was identified by two groups independently using different approaches. In this review, we introduce the characteristics of DINE / ECEL1 and focus on the mechanism underlying the transcriptional regulation of DINE in response to neuronal injury.

Keywords: dine, ecel1, neprilysin, neuron, nerve injury, survival, neuropeptides, leukemia inhibitory, factor (lif)

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Article Details

VOLUME: 11
ISSUE: 5
Year: 2004
Page: [451 - 460]
Pages: 10
DOI: 10.2174/0929866043406526
Price: $58

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