Small Molecule Antagonists of the Tachykinin NK2 Receptor [General Reviews]

Author(s): Daniela Fattori , Maria Altamura , Carlo Alberto Maggi .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 4 , Issue 3 , 2004

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Abstract:

The NK2 receptor (member of the tachykinin receptor family) is mainly located in the smooth muscle of the urinary, respiratory and gastrointestinal tracts, with limited presence in the CNS. This has raised interest in tachykinin NK2 receptor antagonists for the treatment of urological disorders, asthma. This review outlines progress done after 1998 in the field of NK2 small molecule antagonists, both acting on the NK1 / NK2, NK2 / NK3, NK1 / NK2 / NK3 receptors and selective for the NK2 one.

Keywords: nk2 receptor antagonists

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2004
Page: [331 - 340]
Pages: 10
DOI: 10.2174/1389557043487376
Price: $58

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