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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Facile Synthesis of Dibenzylated p-tert-Butylcalix[4]Crowns Under Non- Diluted Reaction Conditions

Author(s): Hirohito Tsue, Tatsuya Takimoto, Rui Tamura, Chieko Kikuchi and Shunitz Tanaka

Volume 1, Issue 3, 2004

Page: [276 - 279] Pages: 4

DOI: 10.2174/1570178043401117

Price: $65

Abstract

The straightforward synthesis of calix[4]crown derivatives in excellent yields under non-diluted reaction conditions is described. The reactions proceed smoothly at ordinary temperature and substrate concentrations of up to 1 M. Theoretical calculations on the reaction intermediates indicate that preorganization originating from the coordination of oxygen atoms to sodium ions plays an important role in the reaction

Keywords: calix[4]crown, calix[4]arene, cyclization, conformation, reaction mechanism


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