Highly Diastereoselective Methylation of Five-Ring N,O-Acetals

Title: Highly Diastereoselective Methylation of Five-Ring N,O-Acetals

Volume: 1 Issue: 3

Author(s): Martin Brunner, Thomas Straub, Pauli Saarenketo, Kari Rissanen and Ari M. P. Koskinen

Affiliation:

Keywords: amino acids, alkylation, diastereoselectivity

Abstract: Highly diastereoselective methylation of (2S,4S)- and (2R,4S)-3-tert-butyl 4-methyl 2-tertbutyloxazolidine- 3,4-dicarboxylate (1a / b) is reported. The relative and absolute configuration of the methylated products was assigned by NOESY and confirmed by a crystal structure of 1a.

Cite this article as:

Brunner Martin, Straub Thomas, Saarenketo Pauli, Rissanen Kari and Koskinen M. P. Ari, Highly Diastereoselective Methylation of Five-Ring N,O-Acetals, Letters in Organic Chemistry 2004; 1 (3) . https://dx.doi.org/10.2174/1570178043400929