Mild and Most Efficient Silylcyanation of Aldehydes Catalyzed by Cesium Fluoride

Author(s): Sung Soo Kim, Dae Ho Song.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 3 , 2004

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Abstract:

Cesium fluoride (CsF) catalyzes the addition of trimethylsilyl cyanide (TMSCN) to various aldehydes. Aromatic, aliphatic, cyclic and heterocyclic aldehydes have been converted into the corresponding trimethylsilyl ethers. Most of the aldehydes show over 99% yield for 20min. The mechanism of silylcyanation has been proposed.

Keywords: silylcyanation, aldehydes, tmscn, cesium fluoride

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Article Details

VOLUME: 1
ISSUE: 3
Year: 2004
Page: [264 - 267]
Pages: 4
DOI: 10.2174/1570178043400884
Price: $65

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