Synthesis of Alicyclic β-lactams via the Ugi Reaction on a Solid Support

Author(s): S. Gedey, J. Van der Eycken, F. Fulop.

Journal Name: Letters in Organic Chemistry

Volume 1 , Issue 3 , 2004

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Abstract:

Via the Ugi 4-centre 3-component reaction (U-4C-3CR), bicyclic cis-2-azetidinone derivatives were synthetised from cyclic β-amino acids on Super Acid Sensitive Resin (Sasrin). 2-, 3- or 4-Formylbenzoic acid was immobilised on the resin through its carboxy function. The U-4C-3CR was also carried out in solution, making use of scavenger resins for purification.

Keywords: ugi reaction, amino acids, solid support, sasrin resin, solid-phase scavengers

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Article Details

VOLUME: 1
ISSUE: 3
Year: 2004
Page: [215 - 220]
Pages: 6
DOI: 10.2174/1570178043401153
Price: $65