Mini-Reviews in Medicinal Chemistry


Cellular and Physiological Effects of Probiotics and Prebiotics

Author(s): Philippe Marteau, Philippe Seksik, Patricia Lepage and Joel Dore

Affiliation: Service d'Hepato-Gastroenterologie, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75908 Paris CEDEX 15, France.


We review the present knowledge on the biological mechanisms of action of probiotics and prebiotics. They include direct effects in the intestinal lumen or on intestinal or immune cells, and indirect mechanisms through modulation of the endogenous microflora (composition or functions such as butyrate production) or of the immune system.

Keywords: probiotics, prebiotics, mechanisms of action, intestinal flora, intestinal immune system, cytokines, butyrate production

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Article Details

Page: [889 - 896]
Pages: 8
DOI: 10.2174/1389557043403369