Amide Mono Thioxylated Derivatives of MEN 10627

Author(s): M. Altamura, G. Balacco, A. Giolitti, A. Guidi, R. Patacchini, A. R. Renzetti, A. Triolo, C. A. Maggi.

Journal Name: Letters in Drug Design & Discovery

Volume 1 , Issue 3 , 2004

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Abstract:

The thioxylation of the potent Neurokinin A antagonist MEN 10627 by Lawessons reagent showed to be potentially useful for the post-synthetic manipulation of the related family of structurally peculiar bicyclic hexapeptides, whose synthesis in combinatorial manner has been recently described.

Keywords: tachykinins, thiopeptides, thioxopeptides, lawesson reagent, atp, anti-ischaemic drugs

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Article Details

VOLUME: 1
ISSUE: 3
Year: 2004
Page: [285 - 288]
Pages: 4
DOI: 10.2174/1570180043398966
Price: $58

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