Prevention of Cell Damage in Ischaemic-Reperfusion: Mitochondrial Respiratory Chain as a Pharmacological Target

Author(s): D. Morin, R. Zini, J. P. Tillement, A. Berdeaux.

Journal Name: Letters in Drug Design & Discovery

Volume 1 , Issue 3 , 2004

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Ischaemic diseases, a major public health problem worldwide, are associated with a decrease in oxygen supply to mitochondria that impairs respiration, energy production and constitute stimuli for cell death. This paper summarises the pharmacological strategies targeting the mitochondrial respiratory chain, which represents an interesting therapeutic perspective.

Keywords: Ischaemia, reperfusion, mitochondrion, respiratory chain, atp, anti-ischaemic drugs

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Article Details

Year: 2004
Page: [279 - 284]
Pages: 6
DOI: 10.2174/1570180043398803
Price: $65

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