New Drug Design for Gene Therapy - Taking Advantage of Introns

Author(s): Shi-Lung Lin, Shao-Yao Ying.

Journal Name: Letters in Drug Design & Discovery

Volume 1 , Issue 3 , 2004

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Abstract:

A novel gene modulation system was identified within mammalian introns, regulating intracellular gene transcripts homologous to certain 5-proximal non-snRNP-binding regions of spliced introns. This gene modulation system can be manipulated for the analysis of gene function and development of gene-specific therapeutics, using artificial introns with 5-proximal hairpin inserts.

Keywords: artificial intron, posttranscriptional gene silencing, pol-II-directed rna interference (rnai), d-rnai, mirna generation, rna splicing, intron-mediated enhancement (ime)

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Article Details

VOLUME: 1
ISSUE: 3
Year: 2004
Page: [256 - 262]
Pages: 7
DOI: 10.2174/1570180043398939
Price: $58

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