Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Advanced Pharmacophore Model of Non-Competitive AMPA Antagonist 2,3-benzodiazepines

Author(s): B. Rezessy, S. Solyom.

Abstract:

Detailed SAR examination and DIStance COmparison (DISCO) computation were used for identification and superposition of common structural features of 2,3-benzodiazepines with high affinity to an allosteric AMPA binding site. Two similar 4-point models were identified; both contained 2 donor sites, a donor atom and a hydrophobic centre. At one of the donor sites a characteristic difference between the two models was observed.

Keywords: non-competitive ampa antagonist,, 2,3-benzodiazepines, pharmacophore model, disco

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Article Details

VOLUME: 1
ISSUE: 3
Year: 2004
Page: [217 - 223]
Pages: 7
DOI: 10.2174/1570180043398948
Price: $58