Development of Organoiron Methodology for the C8-C16 Dienylamine Segment of the Streptogramin Antibiotics

Author(s): Fahim Ahmed, Yeyu Cao, William A. Donaldson.

Journal Name: Letters in Organic Chemistry

Volume 2 , Issue 3 , 2005

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Abstract:

Methodology for preparation of the C8-C16 dienylamine segment of the streptogramin antibiotics is based on a diastereoselective nitrile oxide-olefin cycloaddition to a (triene)iron complex. The Fe(CO)3 adjunct also serves as a protecting group for the subsequent reductive hydrolysis of the isoxazoline ring.

Keywords: streptogramin antibiotics, (diene)iron complexes, cyclocondensation

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Article Details

VOLUME: 2
ISSUE: 3
Year: 2005
Page: [222 - 225]
Pages: 4
DOI: 10.2174/1570178053765366
Price: $65

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