New Approaches for the Treatment of Pain: The GDNF Family of Neurotrophic Growth Factors

Author(s): Dinah W. Y. Sah , Michael H. Ossipov , Anthony Rossomando , Laura Silvian , Frank Porreca .

Journal Name: Current Topics in Medicinal Chemistry

Volume 5 , Issue 6 , 2005

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Abstract:

This article focuses on the GDNF family of neurotrophic factors as a potential new class of therapeutics for neuropathic pain, with a particular emphasis on the ligands, artemin and GDNF. In vivo activity of the ligands, expression of ligands and receptors after peripheral nerve injury, and modulation of nerve injury-induced changes by the ligands are reviewed in detail. Structural considerations, particularly with regard to implications for binding interactions and biological activity are discussed.

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Article Details

VOLUME: 5
ISSUE: 6
Year: 2005
Page: [577 - 583]
Pages: 7
DOI: 10.2174/1568026054367593
Price: $58

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