Abstract
Lack of highly effective and safe therapeutics for hepatitis C virus (HCV) infection provides an opportunity as well as a challenge to discover novel and potent anti-HCV drugs. HCV NS5B RNA-dependent RNA polymerase (RdRp) is responsible for viral genome replication and thus constitutes a valid target for therapeutic intervention. To date, numerous HCV NS5B RdRp inhibitors have been discovered. This review focuses on the recent advances in discovery, mechanism of action studies and biological characterization of several distinct classes of potent inhibitors for NS5B RdRp. The clinical efficacy and developmental status of several promising compounds are also outlined.
Keywords: Hepatitis C virus, HCV, NS5B RNA-dependent RNA polymerase, polymerase inhibitor, structure-activity relationship, nucleoside analogue, non-nucleoside inhibitor, allosteric inhibitor, mechanism of action, drug resistance
Mini-Reviews in Medicinal Chemistry
Title: Recent Advances in Discovery and Development of Promising Therapeutics against Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase
Volume: 5 Issue: 12
Author(s): Jim Z. Wu, Nanhua Yao, Michelle Walker and Zhi Hong
Affiliation:
Keywords: Hepatitis C virus, HCV, NS5B RNA-dependent RNA polymerase, polymerase inhibitor, structure-activity relationship, nucleoside analogue, non-nucleoside inhibitor, allosteric inhibitor, mechanism of action, drug resistance
Abstract: Lack of highly effective and safe therapeutics for hepatitis C virus (HCV) infection provides an opportunity as well as a challenge to discover novel and potent anti-HCV drugs. HCV NS5B RNA-dependent RNA polymerase (RdRp) is responsible for viral genome replication and thus constitutes a valid target for therapeutic intervention. To date, numerous HCV NS5B RdRp inhibitors have been discovered. This review focuses on the recent advances in discovery, mechanism of action studies and biological characterization of several distinct classes of potent inhibitors for NS5B RdRp. The clinical efficacy and developmental status of several promising compounds are also outlined.
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Cite this article as:
Wu Z. Jim, Yao Nanhua, Walker Michelle and Hong Zhi, Recent Advances in Discovery and Development of Promising Therapeutics against Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase, Mini-Reviews in Medicinal Chemistry 2005; 5 (12) . https://dx.doi.org/10.2174/138955705774933310
DOI https://dx.doi.org/10.2174/138955705774933310 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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