Role of 1,4-Benzothiazine Derivatives in Medicinal Chemistry

Author(s): R. Fringuelli , L. Milanese , F. Schiaffella .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 5 , Issue 12 , 2005

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Abstract:

1,4-Benzothiazine (1,4-BT) derivatives have been reported to exhibit a wide range of pharmacological properties including antifungal, immunostimulating, anti-aldoso-reductase, anti-rheumatic, anti-allergic, vasorelaxant, anti-arrhythmic, anti-hypertensive, neuroprotective and cytotoxic activities. These different effects indicate that 1,4-BT is a template potentially useful in medicinal chemistry research and therapeutic applications.

Keywords: Candida infections, Rheumatoid arthritis, ALDOSE-REDUCTASE INHIBITORS, benzothiazepine nucleus, nimodipine, NEUROPROTECTIVE, anti-tumor

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Article Details

VOLUME: 5
ISSUE: 12
Year: 2005
Page: [1061 - 1073]
Pages: 13
DOI: 10.2174/138955705774933365
Price: $58

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